The web is for information. It was not made to emulate desktop or mobile applications.

That said. Information can mean many things. And there will be hybrids.

You can do offline apps in HTML+CSS+JS right now, but it's a PITA:

var a = document.createElement("a");

a.appendChild(document.createTextNode("hacker news");

a.setAttribute("href", "https://news.ycombinator.com/");

If your app contains information, it's best suited for the www. But if it only contains a canvas, it's more suited as a native app.