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I'm curious as to why bacteria didn't evolve to resist Lysin?


Well, perhaps some have (haven't looked at this closely), however, since in nature the various types of it are only used by specific bacteriophages, i.e. as I understand it they are or tend to be species specific, using a particular one against other species of bacteria should be fruitful.

Then again, interspecies transfer of resistance through e.g. plasmids happens.




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