It's a power whose slogan is "Death to the US" and which has been doggedly working on nuclear weapons for decades. Try and temper the Israel Derangement Syndrome sufficiently to see that the US and the Mideast would be better off without the Iranian theocracy.
It's not their slogan and it doesn't mean "death"- that's just a purposeful literal mistranslation. "Death to" in Farsi translates as "down with" in English, and that's the actual official translation. And they have all reasons to be angry with the US.
Ah, and one thing I think the world would be definitely better without, is a western apartheid state with genocidal tendencies placed in the middle east and hell-bent on conquering land and destroying all opponents, armed to the teeth and supported by the west beyond all reason.
It's inexplicable how you can spout this nonsense. Somehow it makes sense to you that there is a relevant distinction to whether a regime machine-gunning its own citizens is shouting "Death to (insert unrelated country)" or "Down with (insert unrelated country)".
You can say that the US is "unrelated" to Iran only if you have zero knowledge of history, either out of ignorance or, most probably, out of convenience.