The risk is also mitigated because if the gene manipulation causes cancer, it should be relatively restricted to the eye, which can be removed in the worst case.
For a long time, gene therapy was shied away from because of an early case of oncogenesis with a lentiviral vector: https://pdfs.semanticscholar.org/cba7/d43412c1709861aea218e4...
The risk is also mitigated because if the gene manipulation causes cancer, it should be relatively restricted to the eye, which can be removed in the worst case.
For a long time, gene therapy was shied away from because of an early case of oncogenesis with a lentiviral vector: https://pdfs.semanticscholar.org/cba7/d43412c1709861aea218e4...