I am sure I don't understand the details, but I do know that NIH is actively funding research investigating neuro-psychiatric disorders employing models based on converting skin cells into neurons.
"Avoiding the stem cell phase eliminates ethical concerns raised when producing what are called pluripotent stem cells, which are similar to embryonic stem cells in their ability to become all adult cell types."
Wait... what??? Why is this even remotely a concern?
The concern is that embryonic stem cells (ESCs) are known to form tumors (teratomas) when transplanted subcutaneously in mice; induced pluripotent stem cells (iPSCs), which are generated by reprogramming ordinary cells into ESC-like pluripotent cells, also form teratomas. This creates challenges for a lot of proposed cell transplantation protocols because pushing pluripotent cells to differentiate into a mature cell type (such as motor neurons) is not 100% efficient, and the transplantation of even a small number of residual pluripotent cells could lead to tumorigenesis. The direct reprogramming method described in this article bypasses the pluripotency step, which could make it safer for clinical use.
I find this hilarious. Not knocking your comment or anything, just fairly sure religious texts didn't say 'thou shall not induce artificial stem cell growth'
> Not knocking your comment or anything, just fairly sure religious texts didn't say 'thou shall not induce artificial stem cell growth'
Well many religious texts disallow altering your body in any way - Jehovas Witnesses, for example, even prohibit blood transfusions, and in Islam it's haram (a sin) to have tattoos.
Pretty certain this would also prohibit doing experimental stuff with stem cells.
This comes off as quite dismissive and a lack of willingness to try to understand others. I'm not aware of any religious texts that proscribe injecting a mixture of sodium thiopental, pancuronium bromide, and potassium chloride[0] for punishment but some people firmly believe that's a violation of one of the Ten Commandments.[1]
It's fine if you disagree. But please try to do so in a manner that shows respect for someone else. To say "just fairly sure religious texts" isn't granting anyone the benefit of the doubt that they may be able to reasonably interpret religious texts to mean something other than a strict literal interpretation.
Can you point to scripture that could be interpreted as standing against stem cell-based cures? Because opposing lethal injection is a pretty strict, literal interpretation of "thou shalt not kill".
If you interpret the harvesting of stem cells as killing a human being, it's pretty direct.
As for capital punishment, one can parse punishment as different from murder, and only the latter as proscribed by "thou shall not kill".
My point is not to discuss interpretation of religious texts. I think it's important to take the time to try to understand where someone is coming from. Dismissing it out of hand prevents you from both understanding and hopefully being understood. You can understand and follow someone's logic without necessarily agreeing with it.
I want to clarify context here because I'm not sure you read this thread much less the article: Treatment from natural stem cells is old news, a while ago we discovered how to convert specialized cells into artificial stem cells then into (other) specialized cells, and now this research demonstrates converting between specialized cells without an intermediary "blank slate" stem cell.
No one is dismissing religiously inspired ethical arguments "out of hand" - religions have some time-tested philosophical/ethical answers - but a post like
> Or maybe also people who have religious views about stem cell research?
requires a bit more meat to be taken seriously.
You know religions don't talk about stem cells. As you said, it's about interpretations... and we're not mind readers, we don't know what yours is. Communicate your specific concerns and reasoning if you want people to follow your logic.
Otherwise, the immediate assumption is that you're suggesting the bible literally says "don't mess with stem cells" - which is funny.
I think you may be assuming a position I have been very clear not to make. I'm responding explicitly to this exchange:
'ada1981> Or maybe also people who have religious views about stem cell research?
'nawgszy> I find this hilarious. Not knocking your comment or anything, just fairly sure religious texts didn't say 'thou shall not induce artificial stem cell growth'
You're right in that the comment by 'ada1981 requires more meat, but that doesn't mean you dismiss it because it's not there: if you want to engage you ask for it or at least assume the most charitable interpretation and acknowledge where you're making charitable assumptions. Neither 'ada1981 nor myself have aligned ourselves with the positions of those that hold these religious views (and 'ada1981 has commented further down that they don't hold this opinion). And that's getting to the heart of my point: we can understand others opinions without necessarily agreeing with them.
You're exactly right: we're not mind readers. And I've tried very hard to be clear what mine is: that to have earnest, meaningful, and constructive discussion we need to strive to understand other's points of view.
I've found Daniel Dennett's explanation of Rapoport's Rules to be very helpful, and explains the position much better than I:
This is what I'm pushing against. I would argue that assuming the simplistic immediate assumption of literal interpretation is uncharitable.
If you're reading into my comments that I hold any particular views with respect to stem cell research or treatment, please point them out, because that's not my intent and I've tried my best to not include any (and to see explain various points of view fairly), and I don't think you can find such a claim. My interest is much more in figuring out how people can productively discuss contentious topics. And that's something I can work on as well.
Regardless, I've derailed this much more than I ever intended, so I'll sign off this thread. Best, and I hope you have a good day!
Edit to add: FWIW, I understand where you're coming from with respect to the article and its implications regarding some past ethical concerns. That doesn't obviate how one discusses the topic with others. Almost by definition when we disagree with someone we're going to find something prima facie unreasonable.
I would counter that interpreting religious texts as an overall activity is not a reasonable one.
It is good an reasonable to show people respect but the same isn't owed to beliefs. Mysticism has an undue influence worldwide on the legality of all sorts of things beyond stem cell research. We shouldn't be afraid to call out, or even laugh at this kind of superstition.
> It is good an reasonable to show people respect but the same isn't owed to beliefs
I agree. This is exactly why I wrote as I did in the above:
> willingness to try to understand others
> try to do so in a manner that shows respect for someone else
> granting anyone the benefit of the doubt that they may be able to reasonably interpret religious texts to mean something other than a strict literal interpretation.
This can charitably (and without much of a stretch) read as "granting anyone the benefit of the doubt that they may be able to reasonably interpret <whatever> in a way that may differ from yours". It's not limited to interpretation of religious texts.
And below:
> I think it's important to take the time to try to understand where someone is coming from. Dismissing it out of hand prevents you from both understanding and hopefully being understood. You can understand and follow someone's logic without necessarily agreeing with it.
You comment:
> I would counter that interpreting religious texts as an overall activity is not a reasonable one.
Which is why I elaborated below:
> My point is not to discuss interpretation of religious texts.
If you expect others to understand your point of you (much less come to agree with it), I believe it's incumbent on you to understand theirs. If you've already written off or otherwise dismissed others, there's little point in discussion.
> You can understand and follow someone's logic without necessarily agreeing with it.
Religion isn't logic- it is indoctrinated superstition. There are no reasons to understand. Faith is undebatable.
Certainly being combative won't win anybody over, we all know that.
But there is no real understanding to be gained debating with someone who has derived their position from an ancient text they believe to be sacred. I don't care if their interpretation is "reasonable" or not...I just don't see how their divining rod should be entering public debate.
What is your goal? A perfectly rational society? Does that take into account that human psychology (the behavior, not the science) is not (completely, if at all) rational? (I'd argue that the goal of a rational society specifically takes into account this inherent non-rational behavior, both in ourselves and others.) How do you want to get there? Do you want to convince those that don't agree with you? Are you yourself open to having your opinion changed? These in my opinion on are both difficult problems and problems worth tackling.
If the religion aspect of it is a sticking point for you, substitute anything over which people strongly disagree. Where do you draw the line as to what's worthwhile discussing or who it's worthwhile discussing with? This is really the crux of what I've been trying to express.
As for "their divining rod should not be entering public debate at all", there are a large number of people who do hold religious beliefs, and are part of the public. Public debate is going to include such discussion because it's a part of who people are. Are you going to shun them? Segregate yourself from them? These are clearly straw men, and I don't ascribe them to you. Don't get me wrong, I don't have an answer to this, and likely there needs to be a varied approach as people themselves are varied. But I do think that not engaging with or dismissing each other if we're acting charitably and in good faith is not a solution.
(And faith certainly is debatable: there's a long history of theological debate which includes debates about faith, both in the particulars as what is believed and the nature of faith itself.)
Anyway, this is likely the last I'll post in this thread. Best.
It just seems to me that all sorts of people, in the US especially, have vague religious opposition to any sort of developments involving the use of stem cells (and related things).
In human neuroscience we cannot ethically take living human brain samples. For example, many autism researchers would like to examine how drugs can affect neurotransmitter pathways in neurons from autistic humans, but we cannot get those neurons.
Recent research is getting funded in which skin cells, which can be ethically collected, and are coaxed into neurons. While there are bound to be differences between these neurons and 'real' neurons from the brain, it is a big step forward.
papers with findings exactly like this one have been found to be complete and total fabrications numerous times over the last few years.