Not if you need to maintain any contact fields other than the (short) canned list Highrise offers. We could not use Highrise because of this. (I know nothing about Rails, but I wondered whether it might be related to their inability -- if it's not just refusal -- to add a feature that their users, judging by the forums when I was evaluating, were clamoring for.)
I was frustrated by the 37s attitude. "We don't comment on development plans" was a common refrain from their staff. So... no hints on where you're heading or whether there's any plan to add a feature I so desperately need? And the focus on simplicity over suitability to customer needs was also surprising.
"Use it or don't" seems to be their take on customer relations. It's their business and they can run it how they want and, yes, I can think of lots of rationalizations for the way they do things, but they're not a company I want to do business with. Maybe, as an earlier poster wrote, 92% of their customers are happy. I wonder how many potential customers they've lost.
Maybe it's a good thing: It leaves a place in the market for a better product, and maybe a better company.
We reported a security flaw. They responded as if it was a feature request. We asked whether it would be fixed. They declined to discuss development plans.
There's lots not to like about their attitude (look how they handled their last outage), but we're still customers.