from clinicaltrials.gov:

Eligibility Criteria

Key Inclusion Criteria:

Resectable cutaneous melanoma metastatic to a lymph node and at high risk of recurrence

Complete resection within 13 weeks prior to the first dose of pembrolizumab

Disease free at study entry (after surgery) with no loco-regional relapse or distant metastasis and no clinical evidence of brain metastases

Has an formalin fixed paraffin embedded (FFPE) tumor sample available suitable for sequencing

Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1

Normal organ and marrow function reported at screening

Key Exclusion Criteria:

Prior malignancy, unless no evidence of that disease for at least 5 years prior to study entry

Prior systemic anti-cancer treatment (except surgery and interferon for thick primary melanomas. Radiotherapy after lymph node dissection is permitted)

Live vaccine within 30 days prior to the first dose of pembrolizumab

Transfusion of blood or administration of colony stimulating factors within 2 weeks of the screening blood sample

Active autoimmune disease

Immunodeficiency, systemic steroid therapy, or any other immunosuppressive therapy within 7 days prior to the first dose of pembrolizumab

Solid organ or allogeneic bone marrow transplant

Pneumonitis or a history of (noninfectious) pneumonitis that required steroids

Prior interstitial lung disease

Clinically significant heart failure

Known history of human immunodeficiency virus (HIV)

Known active hepatitis B or C

Active infection requiring treatment

Ages Eligible for Study 18 Years and older (Adult, Older Adult )

Sexes Eligible for Study All

Accepts Healthy Volunteers No

Not meaning to derail the thread, but ... What typo blew up the space shuttle? Challenger was lost when managers in a rush to launch overrode the recommendations of Thiokol engineers. Columbia was lost when a piece of insulation struck the leading edge of the left orbiter wing at launch and the risk to the shuttle was not recognized by those in charge.

Headline is incorrect; Rybelsus, an oral semaglutide, was approved in 2019. Maybe oral Wegovy is the first oral GLP-1 approved for obesity rather than diabetes.

Flip side is the well-known story of when billg actually answered a customer service call: https://www.entrepreneur.com/leadership/that-time-bill-gates...

I was involved in that particular incident, and wrote about it on HN when the story was making headlines.

https://news.ycombinator.com/item?id=957936#958365

Making a big spectacle of doing regular people work, and then normal employees having to go in and actually do it is very in line with my picture of a certain kind of manager. (Your story did not actually come off like this, I just found this a funny interpretation)

Yeah, it was certainly performative rather than actually serving the customer. My hope at the time was that the STARS knowledgebase would show itself to be slow and overloaded and Bill would realize that it was necessary to invest in upgrading it. Strangely it was faster than I had ever seen it, and it just happened to immediately come up with a plausible answer to Bill's query -- almost like it knew its master's hands were on the keyboard.

My obvious guess is that it was under low load because a lot of people were there watching instead of at their desks using it?

that comment should be added to https://news.ycombinator.com/highlights except, since the hightlights are sorted by the time of the comment it's not going to be seen by anyone unless they read all comments to the end...

That is such utter bs it's amazing that Microsoft PR thought that somehow that shows anything of benefit to the suffering users.

It says the second dose was "injected."

yeah, you can do that with needle and syringe.

There must be many thousands of people named Frank Miller, Jr. So something in addition to the name had to be used.

That's why they pulled him aside and asked for his ID?

IIRC, on his deathbed he was complaining about the design of the hospital's suction catheters.

I see a flash of white text on a dark background, then "Application error: a client-side exception has occurred (see the browser console for more information)." in black on the same very dark background. Chrome on Win 10

this is probably happening if you're viewing a note that has been deleted. since i had 10000+ notes created on the day it launched i set up a pg_cron batch to delete empty notes that are >30 min old.

if not, can you share the url you're seeing it on? thanks for letting me know!

i added better error handling for this :)

https://www.alanagoyal.com/error

What is counter-intuitive? In a triangle with sides A=1, B=1, then C=root(2), so C/A is irrational. That's what was so impactful about the discovery.

Imagine not knowing about irrational numbers. You assume all numbers are just integers and fractional ratios between integers. It would be weird (terrifying?) that something as simple as a right triangle would require a whole category of numbers you can't express.

For some reason that feels so weird that it would be that late "discovery"... Once you define a square(sides same length) the length of diagonal is one of the first questions. And this being very weird number is something I believe someone must have thought about long before that point of time.

These are more or less the first people to think about geometry rigorously as an abstract system. Anyone previous would have just pointed to the hypotenuse and said “it’s that length right there” and not asked a further question.

> more or less the first people to think about geometry rigorously as an abstract system.

The first people whose thinking was preserved until the present.

Which is still noteworthy, but a different thing.

OK but at the time it was literally an open research question: given two reals A, B is there always a rational Q such that QA=B? Number theory as such was still in its infancy but I think it's impressive that this was exactly the right question to ask and they understood how important it was.

A lot of early math was done using geometry tools rather than symbolic representation.

If you are drawing a diagram for a building and you need a distance equal to the diagonal of a square, you set your compass to the two points and use that distance. No need to determine that it can't be represented by a comfortable multiple of the sides.

My bad. I was thinking A, B, and C were integers.

The 3/4/5 triangle is rational. The unit right triangle is not. You’ve dropped the “some” from the parent.

For "most" right triangles, yes, C/A is irrational. In fact the triangles for which C/A is rational are vanishingly rare (though Pythagoras proved many important things about them[1])

But before Pythagoras, it was still an open question if for any two reals A, B there might be a rational Q such that QA = B. Whereas we now know that for "most" reals there is no such Q, thanks to Pythagoras.

1: https://en.wikipedia.org/wiki/Pythagorean_triple